The Best Calibers for Hunting Buffalo and Bison: A Comprehensive Comparison

Choosing the right caliber for taking down North America’s toughest game.

When it comes to hunting buffalo and bison, the stakes are high—literally. These massive animals demand respect, skill, and, most importantly, the right caliber. But with so many options out there, how do you choose? Do you go for raw stopping power, long-range precision, or a classic workhorse caliber? Let’s break it down and help you make the right choice for your next hunt.

Caliber Comparisons

Feature .300 Win Mag .338 Lapua .45-70 Gov .375 H&H .30-06
Muzzle Energy
The raw power delivered by the caliber at the muzzle, measured in foot-pounds.
3,600 ft-lbs (.300 Win Mag) 4,700 ft-lbs (.338 Lapua) 2,700 ft-lbs (.45-70 Gov) 4,200 ft-lbs (.375 H&H) 2,800 ft-lbs (.30-06)
Effective Range
The maximum range at which the caliber maintains enough energy to ethically take down large game.
1,000 yards 1,500 yards 200 yards 500 yards 800 yards
Recoil
The level of felt recoil, which can affect accuracy and shooter comfort.
Moderate High Low High Moderate
Ammo Availability
How easy it is to find ammunition for this caliber.
Widely Available Less Common Widely Available Moderately Available Widely Available
Best Use Case
The ideal hunting scenario for this caliber.
Long-range shots on open plains Extreme long-range precision Close-range brush hunting Versatile medium-to-long range All-around hunting

.300 Win Mag

Introduced in 1963, the .300 Win Mag is a versatile long-range caliber that has earned its place as a favorite among big game hunters. It offers a flat trajectory and impressive power, making it ideal for taking down large animals like buffalo at extended distances.

Pros
  • Flat trajectory
  • Excellent long-range performance
  • Widely available ammunition
Cons
  • Moderate recoil
  • Overkill for smaller game

Interesting Fact: The .300 Win Mag is so versatile that it’s used by both hunters and military snipers.

Consider this Caliber If…

You need a long-range powerhouse for open plains.

Shop for .300 Win Mag ammo and rifles today.

.338 Lapua

Developed in the 1980s for military snipers, the .338 Lapua is a beast of a caliber. With extreme range and stopping power, it’s perfect for hunters targeting buffalo in wide-open spaces where precision matters.

Pros
  • Unmatched long-range precision
  • Massive stopping power
  • Ideal for extreme distances
Cons
  • High recoil
  • Expensive ammo
  • Overkill for most hunting scenarios

Interesting Fact: The .338 Lapua holds the record for the longest confirmed sniper kill at over 2,700 yards.

Consider this Caliber If…

You want to hunt buffalo from a mile away.

Find the best deals on .338 Lapua rifles and ammo.

.45-70 Gov

A true classic, the .45-70 Gov has been around since 1873 and is still a favorite for close-range hunting of large, tough animals. Its heavy, slow-moving bullets deliver devastating stopping power, especially in thick brush.

Pros
  • Massive stopping power
  • Low recoil
  • Perfect for close-range encounters
Cons
  • Limited effective range
  • Arched trajectory

Interesting Fact: The .45-70 was originally designed for use in military rifles during the late 19th century.

Consider this Caliber If…

You’re hunting in thick brush or prefer a classic caliber.

See the lowest prices on .45-70 Gov rifles and ammo.

.375 H&H

The .375 H&H Magnum is a legendary big game caliber, known for its versatility and reliability. Introduced in 1912, it has been used to hunt everything from African elephants to North American bison.

Pros
  • Versatile for medium-to-large game
  • Proven reliability
  • Good balance of power and range
Cons
  • High recoil
  • Moderately available ammo

Interesting Fact: The .375 H&H is one of the few calibers legally required for dangerous game hunting in some countries.

Consider this Caliber If…

You want a do-it-all caliber for big game hunting.

Shop for .375 H&H rifles and ammunition now.

.30-06

The .30-06 Springfield is an all-time classic that has been a go-to for hunters since its introduction in 1906. While not as powerful as some of the magnums, it’s more than capable of taking down bison with proper shot placement.

Pros
  • Widely available
  • Manageable recoil
  • Good all-around performance
Cons
  • Less power compared to magnums
  • Limited range for very large game

Interesting Fact: The .30-06 was the standard U.S. military cartridge for nearly 50 years.

Consider this Caliber If…

You want a reliable, all-purpose caliber with manageable recoil.

Find great deals on .30-06 rifles and ammo today.

Conclusion

Choosing the right caliber for hunting buffalo and bison depends on your hunting style and environment. Whether you prefer the long-range precision of the .338 Lapua, the classic stopping power of the .45-70 Gov, or the versatility of the .375 H&H, there’s a caliber that fits your needs. Make your choice wisely, and happy hunting!